Glioma Featured Genes - BrainBase

Based on glioma multi-omics datasets, Student's t test was performed between 11 pairs at multi-omics levels, including:

E4: 4 pairs at the expression level (Glioma vs Normal; GBM vs LGG; IDH wildtype vs IDH mutation; 1p19q noncodel vs 1p19q codel)

M4: 4 pairs at the DNA methylation level (Glioma vs Normal; GBM vs LGG; IDH wildtype vs IDH mutation; 1p19q noncodel vs 1p19q codel)

C3: 3 pairs at the CNV level (GBM vs LGG; IDH wildtype vs IDH mutation; 1p19q noncodel vs 1p19q codel)

Gene Symbols:

Featured gene groups:

UDGs (1,387)

e.g., MGMT, PRKCG

DEGs (8,675)

e.g., IDH1

DMGs (9,448)

e.g., ADAR

DCGs (10,696)

e.g., EGFR

Datasets country/race: China Germany USA Norway Spain Switzerland Netherlands Mostly White

Table definition: < : omics level of the former is is lower than that of the latter (t-test; p-value < 0.001, FDR < 0.01).
> : omics level of the former is higher than that of the latter (t-test; p-value < 0.001, FDR < 0.01).

Gene Symbol	Expression (E4)								DNA methylation (M4)								CNV (C3)
Gene Symbol	Glioma < Normal	Glioma > Normal	GBM < LGG	GBM > LGG	IDH wildtype < IDH mutation	IDH wildtype > IDH mutation	1p19q noncodel < 1p19q codel	1p19q noncodel > 1p19q codel	Glioma < Normal	Glioma > Normal	GBM < LGG	GBM > LGG	IDH wildtype < IDH mutation	IDH wildtype > IDH mutation	1p19q noncodel < 1p19q codel	1p19q noncodel > 1p19q codel	GBM < LGG	GBM > LGG	IDH wildtype < IDH mutation	IDH wildtype > IDH mutation	1p19q noncodel < 1p19q codel	1p19q noncodel > 1p19q codel

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Gene Symbols:

Featured gene groups: