Gene Information - BrainBase

Summary

Gene Symbol:	SART3
Alias:	KIAA0156; RP11-13G14; TIP110; p110
External Link:	GeneCards
Chr:	chr12
Start Site:	108522214
End Site:	108561400
Strand:	-

Gene Symbol	Disease	Type	PMID	Source
SART3	Glioma	mRNA	26881967	-

Drug	Disease	Target	Source	PMID
No data available in table

Specific Gene

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker
-	-	-	-	-

Molecular Role

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Type	Omics	Alteration	Detail	Pathway	Tumor Process	Description	PMID
mRNA	Genomics	NA	NA	NA	NA	NA	26881967
mRNA	Transcriptomics	NA	NA	NA	NA	NA	26881967

Showing 1 to 2 of 2 entries

Regulation axis

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Regulator Type	Regulator Name	Regulator Effect	Signature	Target Type	Target Name	Target Effect	PMID
miRNA	miR-10b	inhibit	SART3	-	-	-	26881967

Showing 1 to 1 of 1 entries

Disease	Subtype	Grade	Species	Tissue / Cell Line	Description	PMID
Glioblastoma	NA	G4	Homo Sapiens	low‐passage GSC	we demonstrate that in heterogeneous GSC, miR-10b regulates cell cycle and alternative splicing, often through the non-canonical targeting via 5'UTRs of its target genes, including MBNL1-3, SART3, and RSRC1. In all cases, the treatment with miR-10b ASO led to targets' derepression, and attenuated growth and progression of established intracranial GBM.	26881967
Glioblastoma	NA	G4	Homo Sapiens	low_passage GBM stem_like cells	The reseachers demonstrate that in heterogeneous GSC, miR-10b regulates cell cycle and alternative splicing, often through the non-canonical targeting via 5'UTRs of its target genes, including MBNL1-3, SART3, and RSRC1. In all cases, the treatment with miR-10b ASO led to targets' derepression, and attenuated growth and progression of established intracranial GBM.	26881967

Student's t test is used for statistical testing and statistical significance is coded as follows:
_****: p-value <= 0.0001; _***: p-value <= 0.001; _**: p-value <= 0.01; _*: p-value <= 0.05; ns: p-value > 0.05.

Genomics

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Sample ID	Glioma Grade	Chr	Start Site	End Site	RET	ALT	Amino Acid Change	Effect	Filter	DNA VAF
TCGA-06-5416-01A	GBM	chr12	108532232	108532232	C	A	p.E553D	missense_variant	PASS	0.1875
TCGA-19-5956-01A	GBM	chr12	108526432	108526432	C	T	p.S679S	synonymous_variant	PASS	0.217821782
TCGA-32-2616-01A	GBM	chr12	108526219	108526219	G	A	p.Y750Y	synonymous_variant	PASS	0.314814815
TCGA-DB-A64V-01A	LGG	chr12	108545158	108545158	G	A	p.A237V	missense_variant	PASS	0.218623482
TCGA-DU-6392-01A	LGG	chr12	108526353	108526353	C	T	p.V706I	missense_variant	PASS	0.452380952

Showing 1 to 5 of 6 entries

G2 vs G3 vs G4
Primary vs Recurrent

Epigenomics

cg23951927 cg20476877 cg24903225 cg19162598 cg01972961 cg27394563 cg13470919 cg05191825 cg06656689 cg03196745 cg14690343 cg11847805 cg14864542 cg03827423 cg21167558 cg14697323 cg16054422 cg13381718 cg05834899

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