Gene Information - BrainBase

Summary

Gene Symbol:	SPRY2
Alias:	hSPRY2
External Link:	GeneCards
Chr:	chr13
Start Site:	80335976
End Site:	80341126
Strand:	-

Gene Symbol	Disease	Type	PMID	Source
SPRY2	Glioma	mRNA	29635363	-

Drug	Disease	Target	Source	PMID
No data available in table

Specific Gene

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker
-	-	-	-	-

Type	Omics	Alteration	Detail	Pathway	Tumor Process	Description	PMID
mRNA	Transcriptomics	up-regulation	NA	ERK; AKT	proliferation	Silencing of SPRY2 increased epidermal growth factor-induced extracellular signal-regulated kinase (ERK) and Akt activation causing premature onset of DNA replication, increased DNA damage, and impaired proliferation, suggesting that SPRY2 suppresses DNA replication stress.	29635363

Regulation axis

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Regulator Type	Regulator Name	Regulator Effect	Signature	Target Type	Target Name	Target Effect	PMID
No data available in table

Showing 0 to 0 of 0 entries

Disease	Subtype	Grade	Species	Tissue / Cell Line	Description	PMID
Glioblastoma	NA	G4	Homo Sapiens	NA	Low SPRY2 expression is associated with better prognosis in malignant glioma patients, suggesting that modulation of SPRY2 may provide a novel avenue for GBM therapies.	29635363

Student's t test is used for statistical testing and statistical significance is coded as follows:
_****: p-value <= 0.0001; _***: p-value <= 0.001; _**: p-value <= 0.01; _*: p-value <= 0.05; ns: p-value > 0.05.

Genomics

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Sample ID	Glioma Grade	Chr	Start Site	End Site	RET	ALT	Amino Acid Change	Effect	Filter	DNA VAF
TCGA-06-5416-01A	GBM	chr13	80336749	80336749	T	C		3_prime_UTR_variant	PASS	0.195652174
TCGA-06-5416-01A	GBM	chr13	80336974	80336974	G	T	p.C244*	stop_gained	PASS	0.467391304
TCGA-06-5416-01A	GBM	chr13	80337581	80337581	G	T	p.S42Y	missense_variant	PASS	0.235294118
TCGA-E1-A7YL-01A	LGG	chr13	80336814	80336817	TGTT	-	p.N297Qfs*57	frameshift_variant	PASS	0.36

Showing 1 to 4 of 4 entries

G2 vs G3 vs G4
Primary vs Recurrent

Epigenomics

cg11436817 cg09833785 cg11653500 cg06585820 cg22369786 cg15374435 cg06125576 cg18607411 cg00185066 cg12781886 cg18032744 cg08421519 cg11207507 cg16766325 cg15629719 cg22417789 cg11599984 cg10438011 cg14883717 cg20259674 cg16157980

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