Gene Information - BrainBase

Summary

Gene Symbol:	YY1AP1
Alias:	YY1AP; HCCA2; YAP
External Link:	GeneCards
Chr:	chr1
Start Site:	155659443
End Site:	155689000
Strand:	-

Gene Symbol	Disease	Type	PMID	Source
YY1AP1	Glioma	mRNA	28759011 33172899	CRMarker

Drug	Disease	Target	Source	PMID
No data available in table

Specific Gene

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker
-	-	-	-	-

Type	Omics	Alteration	Detail	Pathway	Tumor Process	Description	PMID
mRNA	Genomics	copy number variation; mutation	amplification	NA	supression	YAP and TAZ are highly expressed in EGFR-amplified/mutant human GBMs, YAP/TAZ-TEAD directly regulates transcription of SOX2, C-MYC, and EGFR itself to create a feedforward loop to drive survival and proliferation of human GBM cells.	33172899

Regulation axis

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Regulator Type	Regulator Name	Regulator Effect	Signature	Target Type	Target Name	Target Effect	PMID
-	-	-	YY1AP1	DNA	SOX2; C-MYC	promote	33172899
DNA	EGFR	promote	YY1AP1	-	-	-	33172899

Showing 1 to 2 of 2 entries

Disease	Subtype	Grade	Species	Tissue / Cell Line	Description	PMID
Glioblastoma	NA	G4	Drosophila	uman patient-derived GBM stem cells	YAP and TAZ are highly expressed in EGFR-amplified/mutant human GBMs, and their knockdown in EGFR-amplified/mutant GBM cells inhibited proliferation and elicited apoptosis. Our results indicate that YAP/TAZ-TEAD directly regulates transcription of SOX2, C-MYC, and EGFR itself to create a feedforward loop to drive survival and proliferation of human GBM cells. Moreover, the benzoporphyrin derivative verteporfin, a disruptor of YAP/TAZ-TEAD-mediated transcription, preferentially induced apoptosis of cultured patient-derived EGFR-amplified/mutant GBM cells, suppressed expression of YAP/TAZ transcriptional targets, including EGFR, and conferred significant survival benefit in an orthotopic xenograft GBM model. Our efforts led us to design and initiate a phase 0 clinical trial of Visudyne, an FDA-approved liposomal formulation of verteporfin, where we used intraoperative fluorescence to observe verteporfin uptake into tumor cells in GBM tumors in human patients.	33172899

Student's t test is used for statistical testing and statistical significance is coded as follows:
_****: p-value <= 0.0001; _***: p-value <= 0.001; _**: p-value <= 0.01; _*: p-value <= 0.05; ns: p-value > 0.05.

Genomics

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Sample ID	Glioma Grade	Chr	Start Site	End Site	RET	ALT	Amino Acid Change	Effect	Filter	DNA VAF
TCGA-06-5416-01A	GBM	chr1	155660883	155660883	G	A	p.R389W	missense_variant	PASS	0.239130435
TCGA-06-5416-01A	GBM	chr1	155679432	155679432	G	T	p.N100K	missense_variant	PASS	0.238095238
TCGA-16-0846-01A	GBM	chr1	155660180	155660180	A	T	p.V623D	missense_variant	PASS	0.337837838
TCGA-26-5139-01A	GBM	chr1	155676687	155676687	A	G	p.F128S	missense_variant	PASS	0.374485597
TCGA-32-2616-01A	GBM	chr1	155660205	155660205	C	T	p.G615S	missense_variant	PASS	0.283950617

Showing 1 to 5 of 10 entries

G2 vs G3 vs G4
Primary vs Recurrent

Epigenomics

cg10095967 cg00061769 cg02752934 cg14837416 cg27114086 cg06437799 cg22802773 cg18277007 cg08550626 cg19360850 cg13985135 cg01466020 cg04911728 cg01953152 cg17077171 cg16676300 cg13088939

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