Accession PRJCA000361
Title Genome-maps of histone H3 acetylation and gene expression profiles in K562 cells upon ANP32A knockdown and scramble control.
Relevance Model organism
Data types Epigenomics
Organisms Homo sapiens
Description ANP32A, acidic leucine-rich nuclear phosphoprotein, binds directly to histone tails, preferentially to unmodified histone H3 tails, and associates with histone acetylation modification. Aberrant ANP32A expression has been observed in many solid tumors, which involves in diverse processes depending on the cell context, yet mechanisms are still unknown. Furthermore, there has been no specific investigation into the role of ANP32A in acute myeloid leukemia (AML). To explore the function of ANP32A in AML, we analyzed the effect of ANP32A knockdown on the genome-wide acetyl-H3 enrichment and gene expression.
Sample scope Human leukemia cells
Release date 2019-12-30
Publication
PubMed ID Article title Journal name DOI Year
29467488 ANP32A regulates histone H3 acetylation and promotes leukemogenesis Leukemia 10.1038/s41375-018-0010-7 2018
Submitter Xuejing    Yang  (yangxj@big.ac.cn)
Organization Beijing Institute of Genomics
Submission date 2017-03-02

Project Data

Resource name Description
BioSample (10)  show -
GSA (1) -
CRA000196 CRA_196