Description |
ANP32A, acidic leucine-rich nuclear phosphoprotein, binds directly to histone tails, preferentially to unmodified histone H3 tails, and associates with histone acetylation modification. Aberrant ANP32A expression has been observed in many solid tumors, which involves in diverse processes depending on the cell context, yet mechanisms are still unknown. Furthermore, there has been no specific investigation into the role of ANP32A in acute myeloid leukemia (AML). To explore the function of ANP32A in AML, we analyzed the effect of ANP32A knockdown on the genome-wide acetyl-H3 enrichment and gene expression. |