| 项目编号 | PRJCA000427 | ||||||||||
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| 项目标题 | A Comprehensive Mouse Transcriptomic BodyMap by RNA-seq | ||||||||||
| 涉及领域 | Model organism | ||||||||||
| 数据类型 | Transcriptome or Gene expression | ||||||||||
| 物种名称 | Mus musculus | ||||||||||
| 描述信息 | The mouse has been widely used as a model organism for studying human diseases and for evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity that may be reflected by tissue-specific gene-expression profiles. Here we construct a comprehensive mouse transcriptomic BodyMap across 17 tissues of six-weeks old C57BL/6JJcl mice using RNA-seq. We find different expression patterns between protein-coding and non-coding genes. Liver expressed the least complex transcriptomes, that is, the smallest number of genes detected in liver across all 17 tissues, whereas testis and ovary harbor more complex transcriptomes than other tissues. We report a comprehensive list of tissue-specific genes across 17 tissues, along with a list of 4,781 housekeeping genes in mouse. In addition, we propose a list of 27 consistently and highly expressed genes that can be used as reference controls in expression-profiling analysis. Our study provides a unique resource of mouse gene-expression profiles, which is helpful for further biomedical research. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2017-04-19 | ||||||||||
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| 提交者 | leming shi (pgx@fudan.edu.cn) | ||||||||||
| 提交单位 | Fudan University | ||||||||||
| 提交日期 | 2017-04-19 |