| 项目编号 | PRJCA000524 | ||||||||
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| 项目标题 | Human brain evolution | ||||||||
| 涉及领域 | Evolution | ||||||||
| 先导项目 |
eGPS: evolutionary Genotype-Phenotype Systems biology Cranial Capacity & Structure Genetic mechanism and function of key genes in the evolution of animal brain |
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| 数据类型 |
Phenotype or Genotype
Transcriptome or Gene expression Raw sequence reads |
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| 物种名称 | Macaca mulatta | ||||||||
| 描述信息 | We report the application of RNA sequencing technology for high-throughput profiling of RNA expression in monkey tissues. By obtaining over four billion bases of sequence of brain, liver and muscle from MCPH1 transgenic monkey and two control monkeys. We find that brain tissue showed more differentially expressed genes compared with those in liver and muscle. Finally, we show that This result implies that the over expressed huMCPH1 may have a global impact on multiple organs of the transgenic monkey, and it has the largest impact on the brain in terms of gene numbers. | ||||||||
| 样品范围 | RNA | ||||||||
| 发布日期 | 2020-07-10 | ||||||||
| 项目资金来源 |
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| 提交者 | Lei Shi (leshi@med.umich.edu) | ||||||||
| 提交单位 | Kunming Institute of Zoology(KIZ) | ||||||||
| 提交日期 | 2017-08-17 |