| Accession | PRJCA000639 |
|---|---|
| Title | TKI resistance in childhood Ph-like ALL |
| Relevance | Medical |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression Raw sequence reads |
| Organisms | Homo sapiens |
| Description | Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) comprises of approximately 10-15% of childhood ALL cases, many of whom respond exquisitely to tyrosine kinase inhibitors (TKIs), e.g., imatinib in PDGFRB-rearranged ALL. However, some cases developed drug resistance to TKIs with mechanisms poorly understood. |
| Sample scope | Monoisolate |
| Release date | 2019-11-20 |
| Submitter | Yufeng Gao (gaoyufeng1109@163.com) |
| Organization | Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date | 2017-11-20 |