| Accession |
PRJCA001079 |
| Title |
SSATX, an alternative splicing of sat1, functions as a tumor suppressor in human melanoma cells through RNA-SEQ analysis via regulating Wnt signaling |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Human sat1 gene produces two transcript varients, one translates Spermidine/spermine N-1 acetyltransferase (SSAT1), the rate limiting enzyme in the catabolism of polyamines; the other is SSATX, however, its biological functions remain largely unknown. We found that SSATX knockdown remarkably promoted the proliferation, migration and invasion of human melanoma cells. To gain insights into the mechanism of SSATX-mediated tumor cell proliferation, migration and invasion, we performed RNA-seq analysis of A2058-scramble and A2058-shSSATX cells. Our results revealed that repression of SSATX activated Wnt signaling pathways. |
| Sample scope |
Monoisolate |
| Release date |
2018-10-18 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 31352009
|
Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression
|
Gene
|
10.1016/j.gene.2019.144010
|
2019
|
| 31399345
|
RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay
|
Molecular Cell
|
10.1016/j.molcel.2019.06.033
|
2019
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81672698 31471236
|
|
|
|
| Submitter |
Qiong
Yang (yangqiong@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2018-10-18 |
