1. Home
  2. Browse
  3. PRJCA001105
Accession PRJCA001105
Title Transcriptomic analysis reveals molecular characteristics and transcripts-based diagnostics for growth hormone and non-functioning pituitary adenoma
Relevance Medical
Data types Phenotype or Genotype
Random survey
Transcriptome or Gene expression
Raw sequence reads
Organisms Homo sapiens
Description Pituitary adenomas (PAs) are benign monoclonal tumors arising from adenohypophysial cells, among which the invasive behavior of some PAs renders obstacles for complete surgical resection and tends to recur as aggressive PAs. Understanding of pituitary tumorigenesis and PA invasiveness is urgently needed to direct the operation and postoperative treatments. To determine causal players and identify diagnostic markers in non-functioning (NF) and growth hormone (GH) PA progression and invasion, we assessed transcript changes during PA development and progression by high-throughput transcriptomic analyses and experimental validation. Our approach defines new characteristics in core molecular network for patients at risk for invasive NF-PAs, possibly promoting clinical advances in invasive PA management.
Sample scope Multiisolate
Release date 2020-10-31
Publication
PubMed ID Article title Journal name DOI Year
33391466 Transcriptomic analysis identifies a tumor subtype mRNA classifier for invasive non-functioning pituitary neuroendocrine tumor diagnostics Theranostics 10.7150/thno.47525 2021
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Research and Development Program of China 2016YFA0100601
National Natural Science Foundation of China (NSFC) 81530007
Submitter Gengchao    Wang  (gc.wang@outlook.com)
Organization Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
Submission date 2018-10-31

Project Data

Resource name Description
BioSample (77)  show -
GSA (1) -
CRA001236 PolyA+ mRNA