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项目编号 PRJCA001205
项目标题 Tracking the evolution of Nasopharyngeal carcinoma metastasis
涉及领域 Medical
数据类型 Whole genome sequencing
Exome
Transcriptome or Gene expression
Raw sequence reads
Genome sequencing
物种名称 Homo sapiens
描述信息 Distant metastasis in nasopharyngeal carcinoma (NPC) is poorly understood. We selected 215 paired primary tumor, regional lymph node and distant metastasis samples from 48 NPC patients for genomic/transcriptomic/single-cell sequencing, to study the molecular basis of NPC metastasis and evolution.
样品范围 Multiisolate
发布日期 2022-12-01
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
31484669 Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma Cancer Research 10.1158/0008-5472.CAN-18-3845 2019
33995666 Neoantigen landscape in metastatic nasopharyngeal carcinoma Theranostics 10.7150/thno.53229 2021
40691404 Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma Nature Genetics 10.1038/s41588-025-02253-8 2025
40475399 Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer bioRxiv 10.1101/2025.05.16.654579 2025
39117671 ALYREF promotes the metastasis of nasopharyngeal carcinoma by increasing the stability of NOTCH1 mRNA Cell Death & Disease 10.1038/s41419-024-06959-1 2024
39392128 Single‐cell sequencing analysis reveals the dynamic tumour ecosystems of primary and metastatic lymph nodes in nasopharyngeal carcinoma Journal of Cellular and Molecular Medicine 10.1111/jcmm.70137 2024
36739462 Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance Nature Communications 10.1038/s41467-023-35995-2 2023
39999841 Unveiling familial aggregation of nasopharyngeal carcinoma: Insights from oral microbiome dysbiosis Cell Reports Medicine 10.1016/j.xcrm.2025.101979 2025
39158776 Single-cell resolution profiling of the immune microenvironment in primary and metastatic nasopharyngeal carcinoma Journal of Cancer Research and Clinical Oncology 10.1007/s00432-024-05900-5 2024
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 81572912
提交者 Ming-Yuan Chen (chenmy@sysucc.org.cn)
提交单位 Sun Yat-sen University
提交日期 2019-01-11

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