| Accession |
PRJCA001206 |
| Title |
Relevant exosomic miRs of Early adenocarcinoma of lung |
| Relevance |
Medical |
| Data types |
Raw sequence reads
Exosomal small RNA sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Lung cancer remains the leading cause of cancer morbidity and mortality. A majority of lung cancer is often asymptomatic until advanced or metastatic stage, which is a giant obstacle of lung cancer therapy. This project expect to find the early diagnostic biomarker of lung adenocarcinoma in circulating exosomal miRNAs by a noninvasive method. The blood samples of this project were provided by Peking Union Medical College Hospital (Beijing, china). The total number samples is 21 including 7 lung adenocarcinoma patients (paired) and 7 health controls. Two blood samples from each lung adenocarcinoma patient were collected at the point of pre-operation and post-operation separately. Circulating exosomal RNA in blood was extracted to construct small RNA library using the NEBNext Multiplex Small RNA Library Prep Set for Illumina. The next-generation sequence are performed on illumina HiSeq 2500 System and 50bp single-end reads were generated. |
| Sample scope |
Multiisolate |
| Release date |
2020-12-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 32624699
|
Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma
|
International Journal of Medical Sciences
|
10.7150/ijms.43500
|
2020
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
|
KJZDEWL14
|
|
|
|
| Submitter |
Chongye
Guo (guocy@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2019-01-14 |
