Accession PRJCA001296
Title A specialized metabolic network selectively modulates Arabidopsis root microbiota
Relevance Model organism
Data types Metagenome
Organisms Microbiota
Description Plant specialized metabolites have ecological functions, yet the presence of numerous uncharacterized biosynthetic genes in plant genomes suggests that many molecules remain unknown. Here, we discover a triterpene biosynthetic network in the roots of the small mustard plant Arabidopsis thaliana. Collectively, we have elucidated and reconstituted three divergent pathways for the biosynthesis of root triterpenes, namely thalianin, thalianyl medium-chain fatty acid esters and arabidin. A. thaliana mutants disrupted in the biosynthesis of these compounds have altered root microbiota. In vitro bioassays with purified compounds reveal selective growth modulation activities of pathway metabolites towards root microbiota members and their biochemical transformation and utilization by bacteria, supporting a role for this biosynthetic network in shaping an Arabidopsis-specific root microbial community.
Sample scope Multispecies
Release date 2019-02-28
PubMed ID Article title Journal name DOI Year
A specialized metabolic network selectively modulates Arabidopsis root microbiota Science 10.1126/science.aau6389 2019
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) International (Regional) Cooperation and Exchange Program 31761143017
Submitter Yong-Xin    Liu  (
Organization Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Submission date 2019-02-26

Project Data

Resource name Description
BioSample (140)  show -
GSA (1) -
CRA001464 Arabidopsis triterpenes 16S amplicon