| Accession |
PRJCA001299 |
| Title |
Cooperation between the inflammation and coagulation systems promotes the survival of circulating tumor cells in renal cell carcinoma patients |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
|
| Description |
Most renal cell carcinoma (RCC) patients die from the metastasis or recurrence after the spread of cancer to another organ, but the mechanisms underlying the intravascular survival of circulating tumor cells (CTCs) are incompletely deciphered. Additionally, although elevated plasma C-reactive protein (CRP) levels and thrombocytosis are strongly correlated, and both of them indicated a poor prognosis in RCC patients, the bridge connecting inflammation and coagulation remains poorly understood. To explore the complicated relationship among inflammation, the coagulation system and CTC survival, we obtained viable CTC counts and clinical information for 106 treatment naive patients. In addition, we performed RNA sequencing on peripheral blood leukocytes from 21 of these patients. |
| Sample scope |
Multiisolate |
| Release date |
2021-02-27 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine
|
|
2016I2M1007
|
|
| Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine
|
|
2017I2M2003
|
|
| the PUMC Fund of the Funds for the Central Universities
|
|
3332016027
|
|
|
|
| Submitter |
Liping
Guo (guoliping2010@126.com)
|
| Organization |
Cancer Hospital, Chinese Academy of Medical Sciences |
| Submission date |
2019-02-27 |
