Accession PRJCA001312
Title The chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
Relevance Evolution
Umbrella project

eGPS: evolutionary Genotype-Phenotype Systems biology

Plateau Adaptability

Study on genetic basis of environmental adaptation in Tibetan Plateau

Data types Epigenomics
Raw sequence reads
Organisms Homo sapiens
Description Tibetan's adaptation to high-altitude environment at the Qinghai-Tibetan plateau represents a remarkable case of natural selection during recent human evolution. We generated time series paired ATACseq and RNAseq data in Tibet and Han Chinese's umbilical endothelial cells from normoxia to hypoxia condition. We developed a Variants interpretation method by Paired Expression and Chromatin Accessibility data (vPECA) to accurately identify active REs and active selected REs and their associated regulatory. Our results provide a broad resource of genome-wide hypoxia regulatory network to characterize the effect of genetic variation in high-altitude adaptation, and indicates large-scale maps of variants need proper cell types to understand its act on gene regulation.
Sample scope Multiisolate
Release date 2020-01-05
Publication
PubMed ID Article title Journal name DOI Year
33004791 Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation Nature Communications 10.1038/s41467-020-18638-8 2020
Grants
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) Strategic Priority Research Program of Chinese Academy of Sciences (CAS) XDB13000000
National Natural Science Foundation of China (NSFC) Key Program 91631306
Submitter Yaoxi    He  (heyaoxi@mail.kiz.ac.cn)
Organization Kunming Institute of Zoology, Chinese Academy of Sciences
Submission date 2019-03-05

Project Data

Resource name Description
BioSample (100)  show -