Accession | PRJCA001312 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Title | The chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation | ||||||||||||
Relevance | Evolution | ||||||||||||
Umbrella project |
eGPS: evolutionary Genotype-Phenotype Systems biology Plateau Adaptability Study on genetic basis of environmental adaptation in Tibetan Plateau |
||||||||||||
Data types |
Epigenomics
Raw sequence reads |
||||||||||||
Organisms | Homo sapiens | ||||||||||||
Description | Tibetan's adaptation to high-altitude environment at the Qinghai-Tibetan plateau represents a remarkable case of natural selection during recent human evolution. We generated time series paired ATACseq and RNAseq data in Tibet and Han Chinese's umbilical endothelial cells from normoxia to hypoxia condition. We developed a Variants interpretation method by Paired Expression and Chromatin Accessibility data (vPECA) to accurately identify active REs and active selected REs and their associated regulatory. Our results provide a broad resource of genome-wide hypoxia regulatory network to characterize the effect of genetic variation in high-altitude adaptation, and indicates large-scale maps of variants need proper cell types to understand its act on gene regulation. | ||||||||||||
Sample scope | Multiisolate | ||||||||||||
Release date | 2020-01-05 | ||||||||||||
Publication |
|
||||||||||||
Grants |
|
||||||||||||
Submitter | Yaoxi He (heyaoxi@mail.kiz.ac.cn) | ||||||||||||
Organization | Kunming Institute of Zoology, Chinese Academy of Sciences | ||||||||||||
Submission date | 2019-03-05 |
Resource name | Description |
---|---|
BioSample (100) show | - |