Accession

PRJCA001615

Title

Chromatin remodelers-mediated chromatin accessibility facilitates nascent-to-fetal hematopoietic stem and progenitor cell transition

Relevance

Model organism

Data types

Epigenomics
Raw sequence reads

Organisms

Danio rerio

Description

HSPC development is a dynamic process with different molecular and phenotypical features at different developmental stages. Here, we focused on the dynamic changes in chromatin accessibility and transcriptome features of HSPCs from nascent to fetal states, and uncover the critical role of chromatin remodelers in this process.

Sample scope

Multiisolate

Release date

2020-07-16

Publication

PubMed ID	Article title	Journal name	DOI	Year
32756943	Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates	Blood	10.1182/blood.2020005219	2021

Grants

Agency	program	Grant ID
Chinese Academy of Sciences (CAS)	Strategic Priority Research Program of Chinese Academy of Sciences (CAS)	XDA16010207
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2016YFA0100500
National Natural Science Foundation of China (NSFC)		31830061
National Natural Science Foundation of China (NSFC)		31425016
National Natural Science Foundation of China (NSFC)		81530004
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2017YFA0102600
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2016YFA0100400
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2018YFA0800200
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2018YFA0801000

Submitter

Wen Wang (1510781@tongji.edu.cn)

Organization

Tongji University

Submission date

2019-07-30

Project Data

Resource name	Description
BioSample (24) show	-
SAMC086422	ChIP 3dpf Ncl rep2
SAMC086421	ChIP 3dpf Ncl rep1
SAMC086420	ChIP 3dpf Smarca5 rep2
SAMC086419	ChIP 3dpf Smarca5 rep1
SAMC086418	ChIP 3dpf input rep2
SAMC086417	ChIP 3dpf input rep1
SAMC086416	RNA 3dpf mutant rep2
SAMC086415	RNA 3dpf mutant rep1
SAMC086414	RNA 3 dpf sibling rep2
SAMC086413	RNA 3 dpf sibling rep1
SAMC086412	RNA 3 dpf wt rep2
SAMC086411	RNA 3 dpf wt rep1
SAMC086410	RNA 36 hpf wt rep2
SAMC086409	RNA 36 hpf wt rep1
SAMC086408	ATAC 3 dpf mutant rep2
SAMC086407	ATAC 3 dpf mutant rep1
SAMC086406	ATAC 3 dpf siblings rep2
SAMC086405	ATAC 3 dpf siblings rep1
SAMC086404	ATAC 3 dpf wt rep3
SAMC086403	ATAC 3 dpf wt rep2
SAMC086402	ATAC 3 dpf wt rep1
SAMC086401	ATAC 36 hpf wt rep3
SAMC086400	ATAC 36 hpf wt rep2
SAMC086399	ATAC 36 hpf wt rep1
GSA (1)	-
CRA001858	Chromatin remodelers-mediated chromatin accessibility facilitates nascent-to-fetal hematopoietic stem and progenitor cell transition