| 项目编号 |
PRJCA001620 |
| 项目标题 |
Multi-omics Characterization of Gastric Cancer Evolution under Neoadjuvant Chemotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
Exome
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Neoadjuvant chemotherapy is a common treatment option for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant chemotherapy is underutilized in gastric cancer management, largely due to the lack of biomarkers for patient selection and a limited understanding of resistance mechanisms. Here we performed whole-genome, whole-exome, and RNA-sequencing on 84 clinical samples (including matched pre- and post-treatment tumors) from 35 patients whose responses to neoadjuvant chemotherapy were rigorously defined. We observed increased microsatellite instability and mutation burden in nonresponse tumors. Through comparisons of response vs. nonresponse tumors and pre- vs. post-treatment samples, we found that C10orf71 mutations were associated with treatment resistance, which was supported by in vitro drug response data and potentially through the inhibition of cell cycle; and MYC amplification correlated with treatment sensitivity whereas MDM2 amplification showed the opposite pattern. Neoadjuvant chemotherapy also reshapes the tumor immune signaling and microenvironment. Our study provides a critical basis for developing precision neoadjuvant regimens. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2019-09-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 32133402
|
Multi-omics characterization of molecular features of gastric cancer correlated with response to neoadjuvant chemotherapy
|
Science Advances
|
10.1126/sciadv.aay4211
|
2020
|
| 39164728
|
The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling
|
Journal of Experimental & Clinical Cancer Research
|
10.1186/s13046-024-03152-2
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
31870805
|
|
| The Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding
|
|
ZYLX201701
|
|
| "San Ming" Project of Shenzhen City
|
|
SZSM201612051
|
|
|
|
| 提交者 |
Xiangyu
Gao (xiangyugao@hsc.pku.edu.cn)
|
| 提交单位 |
Beijing Cancer Hospital |
| 提交日期 |
2019-07-25 |
