项目编号 PRJCA001698
项目标题 Landscape and dynamics of single immune cells in hepatocellular carcinoma
涉及领域 Model organism
数据类型 Raw sequence reads
物种名称 Homo sapiens
描述信息 Combining 3 prime and full-length single-cell RNA sequencing technologies, we produced profile of 77,321 CD45+ immune cells for HCC patients from five immune-relevant sites: tumor, adjacent liver, hepatic lymph node (LN), blood, and ascites. Our study not only characterizes the immune composition of HCC but also provides the dynamics of tumor-infiltrating immune cells across tissues, shedding new lights to the immune landscape of HCC.
样品范围 Single cell
发布日期 2019-11-05
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
31675496 Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma Cell 10.1016/j.cell.2019.10.003 2019
40377492 Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis Hepatology Communications 10.1097/HC9.0000000000000714 2025
35577269 Single-Cell Transcriptomics of Liver Cancer: Hype or Insights? Cellular and Molecular Gastroenterology and Hepatology 10.1016/j.jcmgh.2022.04.014 2022
38116005 Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma Frontiers in Immunology 10.3389/fimmu.2023.1320414 2023
38461306 Interrogations of single-cell RNA splicing landscapes with SCASL define new cell identities with physiological relevance Nature Communications 10.1038/s41467-024-46480-9 2024
37379396 Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity Science Advances 10.1126/sciadv.abq7599 2023
40833997 CX 3 CR1 + macrophages interact with HSCs to promote HCC through CD8 + T-cell suppression Hepatology 10.1097/HEP.0000000000001021 2024
38007237 Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma Journal for Immunotherapy of Cancer 10.1136/jitc-2023-007030 2023
37860052 Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis JHEP Reports 10.1016/j.jhepr.2023.100883 2023
37408821 Single-cell RNA-seq Revealed that Altered Tumor Infiltrating Lymphocytes in Cirrhotic Liver Indicate Development of Hepatocellular Carcinoma Journal of Clinical and Translational Hepatology 10.14218/JCTH.2022.00062 2023
36008091 Unraveling the Complexity of Liver Disease One Cell at a Time Seminars in Liver Disease 10.1055/s-0042-1755272 2022
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 31530036
National Natural Science Foundation of China (NSFC) 91742203
Beijing Advanced Innovation Centre for Genomics at Peking University Key Technologies R&D Program 2016YFC0900100
提交者 Zemin Zhang (zemin@pku.edu.cn)
提交单位 Peking University
提交日期 2019-08-26

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