Accession PRJCA001842
Title Genomic and transcriptome profiling of cholangicarcinoma
Relevance Medical
Data types Exome
Transcriptome or Gene expression
Organisms Homo sapiens
Description Cholangiocarcinoma remained a severe threat to human health. Deciphering the genomic and/or transcriptomic profiles of tumor has been proved to be a promising strategy for exploring the mechanism of tumorigenesis and development, which could also provide valuable insights into Cholangiocarcinoma. However, little knowledge has been obtained regarding to how the alteration among different omics levels is connected. Here, using whole exome sequencing and transcriptome sequencing, we performed a thorough evaluation for the landscape of genome and transcriptome in cholangiocarcinoma and illustrate the alteration of tumor on different biological levels. Meanwhile, we also identified the clonal structure of each included tumor sample and discovered different clonal evolution patterns related to patients' survival. Furthermore, we extracted subnetworks that were greatly influenced by tumor clonal/subclonal mutations or transcriptome change. The topology relationship between genes affected by genomic/transcriptomic changes in biological interaction networks revealed that alteration of genome and transcriptome was highly correlated, and somatic mutations located on important genes might affect the expression of numerous genes in close range.
Sample scope Multiisolate
Release date 2020-02-07
Publication
PubMed ID Article title Journal name DOI Year
32231683 Genomic and Transcriptomic Landscape of Tumor Clonal Evolution in Cholangiocarcinoma Frontiers in Genetics 10.3389/fgene.2020.00195 2020
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 2018ZX10302205 National Science and Techonology Major Project
Submitter Huqing    Zhang  (huqzhang@mail.xjtu.edu.cn)
Organization Xi'an Jiaotong University
Submission date 2019-10-17

Project Data

Resource name Description