项目编号 PRJCA001868
项目标题 Single-cell RNA analysis reveals an epithelial-immune dual feature of tumor cells in nasopharyngeal carcinoma
涉及领域 Medical
数据类型 Whole genome sequencing
Transcriptome or Gene expression
物种名称 Homo sapiens
描述信息 We performed single-cell RNA-seq on nasopharyngeal biopsies to define the complex interplay between tumor cells, virus infection, and the TME at single-cell resolution. Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications.
样品范围 Single cell
发布日期 2022-05-28
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
32901110 Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma Cell Research 10.1038/s41422-020-00402-8 2020
41142990 Single-cell and spatial transcriptomics reveal intratumor heterogeneity and immune microenvironment interactions in Natural killer/T-cell lymphoma iScience 10.1016/j.isci.2025.113626 2025
Integrative analysis of ASXL family genes reveals ASXL2 as an immunoregulatory molecule in head and neck squamous cell carcinoma Scientific Reports 10.1038/s41598-024-82815-8 2024
39744943 Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma The Journal of Clinical Investigation 10.1172/JCI182768 2025
38903527 A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment Frontiers in Immunology 10.3389/fimmu.2024.1372432 2024
40624598 A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells Genome Biology 10.1186/s13059-025-03657-9 2025
39231979 Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma Nature Communications 10.1038/s41467-024-52153-4 2024
40543508 Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma Cell Reports Medicine 10.1016/j.xcrm.2025.102200 2025
36412101 BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal Carcinoma Technology in Cancer Research & Treatment 10.1177/15330338221139981 2022
实验材料提供者 Sun Yat-sen University Cancer Center
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) General Program 2018ZX10302205
National Natural Science Foundation of China (NSFC) General Program 31722003
National Natural Science Foundation of China (NSFC) General Program 81520108022
National Natural Science Foundation of China (NSFC) General Program 31770925
National Natural Science Foundation of China (NSFC) General Program 81621004
National Natural Science Foundation of China (NSFC) General Program 81830090
National Natural Science Foundation of China (NSFC) General Program 81772883
National Natural Science Foundation of China (NSFC) General Program 81772895
National Natural Science Foundation of China (NSFC) General Program 81602371
National Natural Science Foundation of China (NSFC) General Program 81230045
Guangzhou Sicence Technology and Innovation Commission General Program 201607020038
National Key Research and development Program 2017YFA0505600
National Key Research and development Program 2016YFC0900102
提交者 Fan Bai (fbai@pku.edu.cn)
提交单位 Peking University
提交日期 2019-10-25

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