| Accession | PRJCA001963 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Title | Convergent genomic signatures of high altitude adaptation among domestic mammals | ||||||||
| Relevance | Evolution | ||||||||
| Umbrella project |
eGPS: evolutionary Genotype-Phenotype Systems biology Plateau Adaptability Analysis of adaptive traits of domestic animals in the Qinghai Tibet Plateau |
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| Data types | Whole genome sequencing | ||||||||
| Organisms | Equus caballus | ||||||||
| Description | Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we utilized 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provides insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | ||||||||
| Sample scope | Monoisolate | ||||||||
| Release date | 2020-01-01 | ||||||||
| Grants |
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| Submitter | Dong-Dong Wu (wudongdong@mail.kiz.ac.cn) | ||||||||
| Organization | Kunming Institute of Zoology, Chinese Academy of Sciences | ||||||||
| Submission date | 2019-11-27 |