| Accession |
PRJCA001978 |
| Title |
Single cell genome sequencing of hepatocellular carcinoma |
| Relevance |
Medical |
| Data types |
Raw sequence reads
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
How genetic aberrations accumulate and evolve during tumor progression is a fundamental question. Recent studies applied single cell DNA sequencing on different cancer types and identified evidence supporting punctuated copy number evolution (PCNE) of tumor cells. However, how hepatocellular carcinoma (HCC) evolve at single cell resolution remains largely unknown. Here, we examined the copy number alteration profiles of 1232 single cells from 10 patients with HCC. |
| Sample scope |
Single cell |
| Release date |
2021-01-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34481846
|
Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma
|
Gastroenterology
|
10.1053/j.gastro.2021.08.052
|
2021
|
|
|
Single-Cell DNA Sequencing Reveals Punctuated and Gradual Clonal Evolution in Hepatocellular Carcinoma
|
Gastroenterology
|
10.1053/j.gastro.2021.08.052
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81972656
|
|
| National Science and Technology Major Project of China
|
|
2018ZX10723204
|
|
|
|
| Submitter |
Ning
Zhang (zhangning@bjmu.edu.cn)
|
| Organization |
First Hospital, Peking University |
| Submission date |
2019-11-30 |
