| Accession |
PRJCA002086 |
| Title |
N6-methyladenosine RNA modification disrupts viral double-stranded RNA structure to evade RLRs sensing |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Mus musculus
|
| Description |
Here we show that METTL3-mediated m6A modification is required for viral immune evasion through attenuating innate immune signaling. During the infection of vesicular stomatitis virus (VSV), METTL3 is recruited from nucleus to cytoplasm to interact with VSV RNA following mediates m6A modification. Furthermore, m6A impairs the double-stranded structure on VSV RNA, which reduces the sensing of RLRs to attenuate the type I IFNs signaling. |
| Sample scope |
Multiisolate |
| Release date |
2021-01-26 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
NA
|
|
|
|
| Submitter |
sun
baofa (sunbf@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2019-12-31 |
