| Accession |
PRJCA002115 |
| Title |
Benzene induces malignant transformation of pre-leukemia cells |
| Relevance |
Environmental |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Benzene is a widely used organic solvent. Long-term chronic benzene exposure mainly damages the hematopoietic system, but the specific mechanism is unknown. This study reproduced the entire process of benzene-induced malignant transformation of AML in mice, and found that benzene exposure up-regulated the malignant proliferation and self-renewal ability of pre_leukemia cells, and may induce more genome damage and leukemia-related mutations. |
| Sample scope |
Monoisolate |
| Release date |
2020-06-07 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Sui
Pinpin (suipinpin0722@163.com)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2020-01-07 |
