Accession PRJCA002151
Title Embryonic attenuated Wnt/b-catenin signaling defines niche location and long- term stem cell fate in hair follicle
Relevance Model organism
Data types Epigenomics
Transcriptome or Gene expression
Raw sequence reads
Organisms Mus
Description Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor cells that acquire long-term self-renewal ability and multipotency at the end of organogenesis. The process through which this is achieved often remains unclear. Here, we discovered that long-term hair follicle stem cells arise from embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/b-catenin signaling. Hair follicle initiation is marked by placode formation, which depends on the activation of Wnt/b-catenin signaling. Soon afterwards, a region with attenuated Wnt/bcatenin signaling emerges in the upper follicle. Embryonic progenitor cells residing in this region gain expression of adult stem cell markers and become definitive long-term hair follicle stem cells at the end of organogenesis. Attenuation of Wnt/b-catenin signaling is a prerequisite for hair follicle stem cell specification because it suppresses Sox9, which is required for stem cell formation.
Sample scope Monoisolate
Release date 2020-01-17
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 2012CB518700
National Natural Science Foundation of China (NSFC) 2014CB849602
Submitter huanwei    huang  (huanghuanwei@nibs.ac.cn)
Organization National Institute of Biological Sciences, Beijing
Submission date 2020-01-17

Project Data

Resource name Description
BioSample (4) -
SAMC133143 WT-ATAC-seq
SAMC133142 KO-ATAC-seq
SAMC133141 WT-RNA-seq
SAMC133140 KO-RNA-seq
GSA (1) -
CRA002299 Embryonic attenuated Wnt/b-catenin signaling defines niche location and long- term stem cell fate in hair follicle