Accession |
PRJCA002151 |
Title |
Embryonic attenuated Wnt/b-catenin signaling defines niche location and long- term stem cell fate in hair follicle |
Relevance |
Model organism |
Data types |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
Organisms |
Mus
|
Description |
Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor cells that acquire long-term self-renewal ability and multipotency at the end of organogenesis. The process through which this is achieved often remains unclear. Here, we discovered that long-term hair follicle stem cells arise from embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/b-catenin signaling. Hair follicle initiation is marked by placode formation, which depends on the activation of Wnt/b-catenin signaling. Soon afterwards, a region with attenuated Wnt/bcatenin signaling emerges in the upper follicle. Embryonic progenitor cells residing in this region gain expression of adult stem cell markers and become definitive long-term hair follicle stem cells at the end of organogenesis. Attenuation of Wnt/b-catenin signaling is a prerequisite for hair follicle stem cell specification because it suppresses Sox9, which is required for stem cell formation. |
Sample scope |
Monoisolate |
Release date |
2020-01-17 |
Grants |
Agency |
program |
Grant ID |
Grant title |
National Natural Science Foundation of China (NSFC)
|
|
2012CB518700
|
|
National Natural Science Foundation of China (NSFC)
|
|
2014CB849602
|
|
|
Submitter |
huanwei
huang (huanghuanwei@nibs.ac.cn)
|
Organization |
National Institute of Biological Sciences, Beijing |
Submission date |
2020-01-17 |