| 项目编号 |
PRJCA002151 |
| 项目标题 |
Embryonic attenuated Wnt/b-catenin signaling defines niche location and long- term stem cell fate in hair follicle |
| 涉及领域 |
Model organism |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus
|
| 描述信息 |
Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor cells that acquire long-term self-renewal ability and multipotency at the end of organogenesis. The process through which this is achieved often remains unclear. Here, we discovered that long-term hair follicle stem cells arise from embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/b-catenin signaling. Hair follicle initiation is marked by placode formation, which depends on the activation of Wnt/b-catenin signaling. Soon afterwards, a region with attenuated Wnt/bcatenin signaling emerges in the upper follicle. Embryonic progenitor cells residing in this region gain expression of adult stem cell markers and become definitive long-term hair follicle stem cells at the end of organogenesis. Attenuation of Wnt/b-catenin signaling is a prerequisite for hair follicle stem cell specification because it suppresses Sox9, which is required for stem cell formation. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2020-01-17 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
2012CB518700
|
|
| National Natural Science Foundation of China (NSFC)
|
|
2014CB849602
|
|
|
|
| 提交者 |
huanwei
huang (huanghuanwei@nibs.ac.cn)
|
| 提交单位 |
National Institute of Biological Sciences, Beijing |
| 提交日期 |
2020-01-17 |
