| Accession |
PRJCA002218 |
| Title |
3D genome analysis identifies dysregulation mechanism of high-risk factors in T-ALL patients |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
Genome sequencing and assembly
|
| Organisms |
Homo sapiens
|
| Description |
Recent studies demonstrate that 3D genome alterations play important roles in tumorigenesis, including the development of hematological malignancies. However, whether alterations in 3D genome organization are associated with T cell acute lymphoblastic leukemia (T-ALL) in patients are largely unknown. Here we report integrated analyses of 3D chromatin structure (BL-Hi-C) and gene expression (RNA-seq) on 18 newly diagnosed T-ALL patients and 4 healthy T cell controls. Our findings highlight the potentially important roles of 3D genome alterations in the etiology and prognosis of T-ALL. |
| Sample scope |
Multiisolate |
| Release date |
2020-02-26 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Hong
Wu (gsmwhlab@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2020-02-16 |
