| Accession |
PRJCA002412 |
| Title |
Genomic Landscape, Evolution and Chemoresistance of Yolk Sac Tumors |
| Relevance |
Medical |
| Data types |
Exome
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Yolk sac tumors (YSTs) are a major histological subtype of malignant ovarian germ cell tumors, and compared to other subtypes, patients with YST have a worse prognosis. The molecular basis of this disease has not been characterized at the genomic level. Here we characterized 41 clinical tumor samples (and related normal samples) from 30 YST patients, with distinct responses to cisplatin-based chemotherapy, through a combination of whole-exome and RNA sequencing. We show that microsatellite instability status and mutational signature are informative of chemoresistance. |
| Sample scope |
Monoisolate |
| Release date |
2020-06-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34117242
|
Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
|
Nature Communications
|
10.1038/s41467-021-23681-0
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Medical Sciences Initiative for Innovative Medicine
|
|
N/A
|
|
|
|
| Submitter |
Jiaxin
Yang (yangjiaxin@pumch.cn)
|
| Organization |
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College |
| Submission date |
2020-03-20 |
