| Accession | PRJCA002451 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Title | Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells | ||||||||
| Relevance | Medical | ||||||||
| Data types |
Transcriptome or Gene expression
Raw sequence reads RIP |
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| Organisms | Mus musculus | ||||||||
| Description | RNA N6-methyladenosine (m6A), the most abundant internal modification of mRNAs, plays key roles in human development and disease. Post-translational methylation are often critical for the dynamic regulation of enzyme activity of the protein complex. However, the role of methylation of the core methyltransferase METTL3/METTL14 in m6A regulation remains elusive. our findings showed that arginine methylation of METTL14 stabilizes the m6A methyltransferase to its substrate RNA, thereby promotes the global m6A modification and mESC endoderm differentiation, suggesting a crosstalk between protein methylation and RNA methylation in gene expression. | ||||||||
| Sample scope | Multiisolate | ||||||||
| Release date | 2020-03-26 | ||||||||
| Grants |
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| Submitter | Cui Jinru (744695539@qq.com) | ||||||||
| Organization | Southern Medical University | ||||||||
| Submission date | 2020-03-26 |