| Accession | PRJCA002454 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Title | A Single-Cell Transcriptomic Atlas of Arterial Aging in Cynomolgus Monkey | ||||||||
| Relevance | Model organism | ||||||||
| Data types |
Transcriptome or Gene expression
Raw sequence reads Genome sequencing |
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| Organisms | Homo sapiens | ||||||||
| Description | Our understanding of how human aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we reported a single-cell transcriptomic survey of aortic arches and coronary arteries in young and old cynomolgus monkeys. Our data defined the molecular signatures of specialized arteries and identified eight novel markers discriminating aortic and coronary vasculature. Gene network analyses characterized transcriptional landmarks that regulate vascular senility and positioned FOXO3A, a longevity-associated transcription factor, as a master regulator gene that was downregulated in six subtypes of monkey vascular cells during aging. Targeted inactivation of FOXO3A in human vascular endothelial cells recapitulated the major phenotypic defects observed in aged monkey arteries, verifying FOXO3A as a functional geroprotective factor in arterial endothelial cells. Our study provides a critical resource for understanding the principles underlying arterial aging and contributes important clues to future treatment of age-associated vascular disorders. | ||||||||
| Sample scope | Monoisolate | ||||||||
| Release date | 2020-03-28 | ||||||||
| Data provider |
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| Biomaterial provider | Pengze Yan | ||||||||
| Grants |
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| Submitter | Shu Zhang (zhshu0917@pku.edu.cn) | ||||||||
| Organization | Peking University | ||||||||
| Submission date | 2020-03-28 |