| Accession |
PRJCA002498 |
| Title |
Genome-wide profiling of histone H3K27 acetylation in fatty liver hemorrhagic syndrome of chickens |
| Relevance |
Agricultural |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Gallus
|
| Description |
Fatty liver hemorrhagic syndrome (FLHS) is a lipid metabolism disorder characterized by dramatic drop in egg production and increased mortality in commercial laying hens. Among that, nutrition is the main reason for FLHS in modern poultry industry, however, little is known about the epigenetic mechanisms by environmental factors of nutrition mediate FLHS disease. To this end, we compared genome-wide cis-regulatory profiles and transcriptome of liver between healthy and HELP (high-energy low-protein) diet-induced FLHS chickens, and we identified widespread acetylic dysregulation in the liver of FLHS group and enriched sequence motifs showing changes in response to disease. Remarkably, we revealed that HELP diet may have an impact on histone modification of H3K27ac and chromatin structure, lead the dysregulation of candidate genes in lipid and energy metabolism and PPARs signaling pathway, which cause the excessive accumulation of fat in liver tissue and induce the formation of FLHS. These findings suggest that epigenetic regulation of gene expression play a vital role in the pathogenesis of metabolic disorders of FLHS, and the therapeutic implications of targeting PPARs pathway in the context of FLHS are of great importance, which may enable us to develop new and specific therapies for FLHS susceptible commercial laying hens. |
| Sample scope |
Multiisolate |
| Release date |
2020-04-07 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33505421
|
Dysregulated H3K27 Acetylation Is Implicated in Fatty Liver Hemorrhagic Syndrome in Chickens
|
Frontiers in Genetics
|
10.3389/fgene.2020.574167
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
31960690
|
|
|
|
| Submitter |
yaling
zhu (zhuyaling@ahmu.edu.cn)
|
| Organization |
Anihui medical university |
| Submission date |
2020-04-07 |
