Accession

PRJCA002573

Title

Global Characterization of CD45+ Immune Cells States in Peripheral Blood and Synovial Tissues of ACPA-negative and ACPA-positive Rheumatoid Arthritis Patients by Single-cell Sequencing

Relevance

autoimmunity disease

Data types

Transcriptome or Gene expression

Organisms

Homo sapiens

Description

The immune pathogenesis mechanisms that underlie ACPA-positive and ACPA-negative RA are not well understood. Here, we profiled 100,551 cells from peripheral blood and synovial tissue of seven ACPA-positive and seven ACPA-negative RA patients as well as healthy controls by single-cell RNA sequencing, which enabled identification and characterization of specific subsets of immune cells related to RA pathogenesis.

Sample scope

Single cell

Release date

2020-12-31

Publication

PubMed ID	Article title	Journal name	DOI	Year
34404786	Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis	Nature Communications	10.1038/s41467-021-25246-7	2021
38302261	Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-α in rheumatoid arthritis	Annals Of the Rheumatic Diseases	10.1136/ard-2023-224878	2024

Grants

Agency	program	Grant ID	Grant title
Chinese Academy of Medical Science Innovation Fund for Medical Sciences		NA	Immunological pathogenesis of different clinical subtypes of rheumatoid arthritis based on single-cell sequencing

External link

External link	Link description
https://www.pku.edu.cn//	NO. 5 Yiheyuan Road

Submitter

Xuan Zhang (zxpumch2003@sina.com)

Organization

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

Submission date

2020-04-22

Project Data

Resource name	Description
BioSample (60) show	-
SAMC2089072	SLEWSN
SAMC2089068	S219
SAMC2089066	S212
SAMC2089062	S205
SAMC2089058	S204
SAMC2089054	S194
SAMC2089051	C104
SAMC2089047	C103
SAMC2089043	C102
SAMC2089039	C101
SAMC2089034	C48
SAMC2089029	C38
SAMC1350103	synovial membrane of patient RA21
SAMC1350098	PBMC of patient RA21
SAMC1350095	synovial membrane of patient RA20
SAMC1350087	PBMC of patient RA20
SAMC1350083	PBMC of patient RA19
SAMC1350080	synovial membrane of patient RA18
SAMC1350074	PBMC of patient RA18
SAMC1350072	synovial membrane of patient RA17
SAMC1350068	PBMC of patient RA17
SAMC1350067	synovial membrane of patient RA16
SAMC1350063	PBMC of patient RA16
SAMC1350060	synovial fluid of patient RA15
SAMC1350054	PBMC of patient RA15
SAMC1350051	synovial membrane of patient RA14
SAMC1350048	synovial fluid of patient RA14
SAMC1350044	PBMC of patient RA14
SAMC1350041	synovial membrane of patient RA13
SAMC1350037	synovial fluid of patient RA13
SAMC1350033	PBMC of patient RA13
SAMC1350029	synovial membrane of patient RA12
SAMC1350025	synovial fluid of patient RA12
SAMC1350021	PBMC of patient RA12
SAMC1350018	synovial membrane of patient RA11
SAMC1350015	PBMC of patient RA11
SAMC1350010	synovial membrane of patient RA10
SAMC1350006	synovial fluid of patient RA10
SAMC1350002	PBMC of patient RA10
SAMC1349998	synovial membrane of patient RA09
SAMC1349995	PBMC of patient RA09
SAMC1349990	synovial membrane of patient RA08
SAMC1349986	PBMC of patient RA08
SAMC1349983	synovial membrane of patient RA06
SAMC1349979	PBMC of patient RA06
SAMC1349975	synovial membrane of patient RA05
SAMC1349971	PBMC of patient RA05
SAMC1349967	synovial membrane of patient RA04
SAMC1349964	synovial fluid of patient RA04
SAMC1349961	PBMC of patient RA04
SAMC1349957	synovial membrane of patient RA03
SAMC1349953	synovial fluid of patient RA03
SAMC1349949	PBMC of patient RA03
SAMC1349945	synovial membrane of patient RA02
SAMC1349942	PBMC of patient RA02
SAMC1349936	PBMC of patient RA01
SAMC1349933	PBMC of healthy control 4
SAMC1349928	PBMC of healthy control 3
SAMC1349924	PBMC of healthy control 2
SAMC1349922	PBMC of healthy control 1