| Accession |
PRJCA002698 |
| Title |
Multiregional Glioma Single-Cell Transcriptomic Sequencing |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Glioma is a complex malignant neoplasm, treating each case as a dark box obviously could not acquire expected overall prognosis, because subpopulation inside tumor could be core factor which directly influence tumor progression. So, clonal sequencing or single-cell sequencing could be best solution to this problem. Here we combined these two strategies and analyzed more than 6000 single-cell transcriptome of 73 surgery points from 13 glioma and 1 brain metastasis patient. After these cells asigned into normal, immune, tumor and several other groups based on differentially expressed genes and specified TCGA 4 classification gene sets, spacial information of sampling points helped us built up cell type constituent of different part inside tumor, and illustrated invasion patterns during tumor growth. |
| Sample scope |
Single cell |
| Release date |
2020-08-15 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34692159
|
Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies
|
National Science Review
|
10.1093/nsr/nwaa099
|
2020
|
|
|
| Biomaterial provider |
Prof. Tao Jiang |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2016YFC0906000
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2016YFC0906001
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2018YFA0107601
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2017YFA0102702
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2016YFC0902500
|
|
| Beijing Municipal Science & Technology Commission
|
|
Z141100000214009
|
|
|
|
| Submitter |
Xiao-dong
Su (xdsu@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2020-05-19 |
