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Accession PRJCA002715
Title Genomic and transcriptomic characterization of adenocarcinoma at gastroesophageal junction in Chinese patients
Relevance Medical
Data types Whole genome sequencing
Transcriptome or Gene expression
Raw sequence reads
Organisms Homo sapiens
Homo
Description The incidences of adenocarcinoma at the gastroesophageal junction (ACGEJ) are rapidly increasing worldwide in the past few decades. This disease has a dismal 5-year survival rate and lacks specific and effective treatment options. It is thus urgent to apprehend the molecular characteristics of ACGEJ that can serve as potential drug targets and/or prognostic indicators. We have collected biospecimen and clinical information from 124 Chinese ACGEJ patients and generated matched whole-genome and transcriptome sequencing data. Using these data and additional functional experiments on ACGEJ cell lines, we propose to conduct comprehensive genomic and transcriptomic profiling of ACGEJ in Chinese patients.
Sample scope Multiisolate
Release date 2022-05-11
Publication
PubMed ID Article title Journal name DOI Year
33257699 Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction Nature Communications 10.1038/s41467-020-19949-6 2020
35210398 Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma Signal Transduction and Targeted Therapy 10.1038/s41392-022-00873-8 2022
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) N/A
Submitter Chen Wu (chenwu@cicams.ac.cn)
Organization Cancer Hospital, Chinese Academy of Medical Sciences
Submission date 2020-05-21

Project Data

Resource name Description
BioSample (521)  show -