| 项目编号 |
PRJCA002731 |
| 项目标题 |
A single-cell transcriptome atlas of the adult and aged primate retinae |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
Macaca mulatta
|
| 描述信息 |
The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119 520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting the distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type- specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A- rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region- specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understand the molecular and cellular mechanisms underlying human retinal diseases. Together, these datasets are valuable for understanding the molecular characteristics of primate retina, as well as the molecular regulation of aging progression and related diseases. |
| 样品范围 |
single cell and bulk |
| 发布日期 |
2024-03-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 34691611
|
A single-cell transcriptome atlas of the aging human and macaque retina
|
National Science Review
|
10.1093/nsr/nwaa179
|
2021
|
| 39954235
|
Transcriptional Heterogeneity and Differential Response of Rod Photoreceptor Pathway Uncovered by Single‐Cell RNA Sequencing of the Aging Mouse Retina
|
Aging Cell
|
10.1111/acel.70001
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
|
XDA16020601/03
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2019YFA0110100
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81925009
|
|
| Fundamental Research Funds for the Central Universities
|
|
WK2070000174
|
|
| Beijing Brain Initiative of Beijing Municipal Science & Technology Commission
|
|
Z181100001518004
|
|
| The Key Research and Development Program sponsored by the Ministry of Science and Technology
|
|
2020YFA0112200
|
|
|
|
| 提交者 |
Xiaoqun
Wang (xiaoqunwang@ibp.ac.cn)
|
| 提交单位 |
Institute of Biophysics, Chinese Academy of Sciences |
| 提交日期 |
2020-05-24 |
