| 项目编号 | PRJCA002797 | ||||||||||
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| 项目标题 | Regulatory effect and mechanism of nuclear matrix-related long non-coding RNA on liver lipid metabolism and 3D genome | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression Genome sequencing and assembly |
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| 物种名称 | Mus musculus | ||||||||||
| 描述信息 | In eukaryotic cells, chromosomes are folded into higher-level structures at different levels to regulate genome function, but the molecular mechanism of their formation remains unclear. We hypothesized that nuclear matrix-related RNA plays a key regulatory role in the three-dimensional genome, and identified 54 nuclear matrix-related long noncoding RNAs (named NMALTs) from mouse livers. This project intends to continue to explore the in vivo function and mechanism of NMALT1 on the basis of previous research: 1) study the short-term and long-term effects on lipid metabolism through in vivo RNA interference and liver conditional knockout mice; Targets of action, regulatory networks, and effects on the three-dimensional structure of chromatin; 3) To explore the correlation between the expression and genetic variation of homologous genes and human metabolic syndrome. The research of this project may reveal new molecules and mechanism of action that regulate the three-dimensional genome structure, and may provide new targets for the analysis and diagnosis and treatment of human metabolic syndrome. | ||||||||||
| 样品范围 | Monoisolate | ||||||||||
| 发布日期 | 2020-06-04 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Zixiang Yan (yanzx1991@qq.com) | ||||||||||
| 提交单位 | Fudan University | ||||||||||
| 提交日期 | 2020-06-04 |