| Accession |
PRJCA002800 |
| Title |
Evolution under spatially-heterogeneous selection in solid tumors |
| Relevance |
Evolution |
| Data types |
Whole genome sequencing
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Multi-stage tumorigenesis and clonal evolution model described previously indicate that solid tumor is temporally and spatially heterogeneous, samples collected at different time points or spatial positions providing various genetic information. Based on this, we performed three-dimensional micro-dissection and whole-genome sequencing (WGS) for two tumors at a relatively early stage to comprehensively trace the mutation evolutionary process of tumors and decipher their clonal distribution in three dimensions. |
| Sample scope |
Multiisolate |
| Release date |
2022-01-13 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34850073
|
Evolution under Spatially Heterogeneous Selection in Solid Tumors
|
Molecular Biology and Evolution
|
10.1093/molbev/msab335
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
9153130008
|
|
|
|
| Submitter |
Xuemei
Lu (xuemeilu@mail.kiz.ac.cn)
|
| Organization |
Kunming Institute of Zoology, Chinese Academy of Sciences |
| Submission date |
2020-06-05 |
