| 项目编号 |
PRJCA002865 |
| 项目标题 |
A human immune cell landscape in aging and COVID-19 |
| 涉及领域 |
Aging |
| 数据类型 |
Whole genome sequencing
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Age-associated changes in immune cells have been linked with increased risk for infection and cancer. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old research subjects and patients with COVID-19. We found an aging reprogramed immune cell landscape. Notably, aging increased senescent hallmark genes and coronavirus susceptibility gene expression in cell-subtype specificity. Most impressively, COVID-19 increased aging-induced immune cells polarization, inflammation genes and senescent hallmark genes upregulation. An aging-associated dysregulated immune system and upregulated SARS-CoV-2 susceptibility gene expression may account for susceptibility and increased vulnerability of COVID-19 in the elderly. |
| 样品范围 |
Single cell |
| 发布日期 |
2020-06-16 |
| 出版信息 |
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
|
|
2017YFA0105800
|
|
|
|
| 提交者 |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| 提交单位 |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| 提交日期 |
2020-06-16 |
