| Accession |
PRJCA002909 |
| Title |
Single cell RNA sequencing of bladder urothelial carcinoma |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
In order to investigate the microenvironment of bladder urothelial carcinoma, we performed single-cell RNA sequencing on 8 tumor samples and 3 para-tumor samples. We identified 19 different cell types in the BC microenvironment, indicating high intra-tumoral heterogeneity of bladder carcinoma. Most importantly, through correlation analysis using public datasets containing over 3,000 BC samples, we identified a role for inflammatory cancer-associated fibroblasts (iCAFs) in tumor progression, which was significantly related to poor prognosis. |
| Sample scope |
Single cell |
| Release date |
2020-06-24 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81672524
|
|
| Science, Technology and Innovation Commission of Shenzhen Municipality
|
|
JCYJ20180305164838833
|
|
|
|
| Submitter |
Chen
Ke (shenke@hust.edu.cn)
|
| Organization |
Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| Submission date |
2020-06-22 |
