| Accession |
PRJCA002943 |
| Title |
Single-cell Immune Profiling of Mesenchymal Stem Cells Treatments for COVID-19 |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Although many efforts were spent to treat Corona Virus Disease 2019 (COVID-19), the pathogenesis and effective treatments were still absent. We performed human umbilical cord mesenchymal stem cells (hUC-MSCs) treatment for mild/moderate COVID-19 cases. Gene expression profile were detected using single-cell RNA and V(D)J sequencing. We found the functional improvement of effector memory CD4+ T cells, promotion of the anti-infective activities in effector CD8+ T cells, NK cells and plasma cells in convalescent patients after MSCs treatments. We further identified 6 high frequency T cell clonotypes. Notably, we found the global downregulation of AP-1 subunits and dysfunction of ribosomal subunits, which may affect inflammatory response and virus replication. Our results demonstrated the effects of MSCs treatments for mild/ moderate COVID-19 at single-cell resolution. |
| Sample scope |
Multiisolate |
| Release date |
2021-09-16 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81871820
|
|
| Key Research and Development Plan of Hunan Province
|
Key Program
|
2020SK3015
|
|
| Science and Technology Planning Project of Hengyang
|
General Program
|
202010021604
|
|
| Major Project of Hunan Provincial Health Commission
|
Major Program
|
20201914
|
|
|
|
| Submitter |
Zhigang
Xue (xuezg@tongji.edu.cn)
|
| Organization |
Tongji University |
| Submission date |
2020-06-28 |
