Accession

PRJCA003066

Title

Resetting histone modifications during human prenatal germline development

Relevance

Medical

Data types

Epigenomics
Transcriptome or Gene expression

Organisms

Homo sapiens

Description

In this study, we map the genome-wide profiles of three key histone modifications H3K4me3, H3K27me3 and H3K9me3 in human primordial germ cells (hPGCs) from weeks 8 to 23 of gestation for the first time by performing ULI-NChIP-seq to provide a unique roadmap of core histone modifications during hPGC development, which helps to elucidate the architecture of germ cell reprogramming in a hypomethylated DNA environment.

Sample scope

Multiisolate

Release date

2023-01-18

Publication

PubMed ID	Article title	Journal name	DOI	Year
36737434	Resetting histone modifications during human prenatal germline development	Cell Discovery	10.1038/s41421-023-00519-1	2023

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		31721003
National Natural Science Foundation of China (NSFC)		31900621
National Natural Science Foundation of China (NSFC)		31820103009
National Natural Science Foundation of China (NSFC)		31871446
National Natural Science Foundation of China (NSFC)		32270855
National Natural Science Foundation of China (NSFC)		32030022
National Natural Science Foundation of China (NSFC)		31970642
National Natural Science Foundation of China (NSFC)		31871448
National Natural Science Foundation of China (NSFC)		31970642
National Natural Science Foundation of China (NSFC)		32070857
Science and Technology of Shanghai Municipality		19JC1415300
Science and Technology of Shanghai Municipality		21JC1405500
Natural Science Foundation of Shanghai Municipality		21ZR1465500
National Key R&D Program of China		2021YFA1100300
National Key R&D Program of China		2020YFA0509800
National Key R&D Program of China		2021YFC2700300
National Key R&D Program of China		2020YFA0112500
National Key R&D Program of China		2021YFA1302500

Submitter

Shaorong Gao (gaoshaorong@tongji.edu.cn)

Organization

Tongji University

Submission date

2020-07-16

Project Data

Resource name	Description
BioSample (107) show	-
SAMC1398663	RNA Female 21w Negative PGC rep3
SAMC1398659	RNA Female 21w Negative PGC rep2
SAMC1398655	RNA Female 21w Negative PGC rep1
SAMC1398653	RNA Female 21w Positive PGC rep3
SAMC1398649	RNA Female 21w Positive PGC rep2
SAMC1398644	RNA Female 21w Positive PGC rep1
SAMC1398640	RNA Female 14w Negative PGC rep3
SAMC1398636	RNA Female 14w Negative PGC rep2
SAMC1398631	RNA Female 14w Negative PGC rep1
SAMC1398627	RNA Female 14w Positive PGC rep3
SAMC1398620	RNA Female 14w Positive PGC rep2
SAMC1398618	RNA Female 14w Positive PGC rep1
SAMC1398614	RNA Female 8w Positive PGC rep2
SAMC1398610	RNA Female 8w Positive PGC rep1
SAMC1398609	RNA Male 23w Negative PGC rep3
SAMC1398605	RNA Male 23w Negative PGC rep2
SAMC1398601	RNA Male 23w Negative PGC rep1
SAMC1398598	RNA Male 23w Positive PGC rep3
SAMC1398595	RNA Male 23w Positive PGC rep2
SAMC1398592	RNA Male 23w Positive PGC rep1
SAMC1398588	RNA Male 15w Negative PGC rep3
SAMC1398583	RNA Male 15w Negative PGC rep2
SAMC1398580	RNA Male 15w Negative PGC rep1
SAMC1398576	RNA Male 15w Positive PGC rep3
SAMC1398572	RNA Male 15w Positive PGC rep2
SAMC1398569	RNA Male 15w Positive PGC rep1
SAMC1398566	RNA Male 11w Negative PGC rep3
SAMC1398562	RNA Male 11w Negative PGC rep2
SAMC1398558	RNA Male 11w Negative PGC rep1
SAMC1398556	RNA Male 11w Positive PGC rep3
SAMC1398552	RNA Male 11w Positive PGC rep2
SAMC1398548	RNA Male 11w Positive PGC rep1
SAMC1398544	RNA Male 8w Positive PGC rep3
SAMC1398540	RNA Male 8w Positive PGC rep2
SAMC1398536	RNA Male 8w Positive PGC rep1
SAMC1398533	ChIP H3K9me3 Female 21w Negative PGC rep2
SAMC1398530	ChIP H3K9me3 Female 21w Negative PGC rep1
SAMC1398526	ChIP H3K9me3 Female 21w Positive PGC rep2
SAMC1398521	ChIP H3K9me3 Female 21w Positive PGC rep1
SAMC1398516	ChIP H3K27me3 Female 21w Negative PGC rep2
SAMC1398514	ChIP H3K27me3 Female 21w Negative PGC rep1
SAMC1398510	ChIP H3K27me3 Female 21w Positive PGC rep2
SAMC1398507	ChIP H3K27me3 Female 21w Positive PGC rep1
SAMC1398503	ChIP H3K4me3 Female 21w Negative PGC rep2
SAMC1398499	ChIP H3K4me3 Female 21w Negative PGC rep1
SAMC1398497	ChIP H3K4me3 Female 21w Positive PGC
SAMC1398493	ChIP H3K27me3 Female 15w Positive PGC rep2
SAMC1398489	ChIP H3K27me3 Female 15w Positive PGC rep1
SAMC1398486	ChIP H3K4me3 Female 15w Positive PGC rep2
SAMC1398482	ChIP H3K4me3 Female 15w Positive PGC rep1
SAMC1398478	ChIP H3K9me3 Female 14w Negative PGC
SAMC1398474	ChIP H3K27me3 Female 14w Positive PGC rep2
SAMC1398470	ChIP H3K27me3 Female 14w Positive PGC rep1
SAMC1398468	ChIP H3K4me3 Female 14w Positive PGC rep2
SAMC1398464	ChIP H3K4me3 Female 14w Positive PGC rep1
SAMC1398460	ChIP H3K9me3 Female 10w Negative PGC
SAMC1398458	ChIP H3K27me3 Female 10w Negative PGC
SAMC1398454	ChIP H3K27me3 Female 10w Positive PGC rep2
SAMC1398450	ChIP H3K27me3 Female 10w Positive PGC rep1
SAMC1398446	ChIP H3K4me3 Female 10w Negative PGC
SAMC1398442	ChIP H3K4me3 Female 10w Positive PGC rep2
SAMC1398438	ChIP H3K4me3 Female 10w Positive PGC rep1
SAMC1398436	ChIP H3K27me3 Female 8w Positive PGC
SAMC1398432	ChIP H3K4me3 Female 8w Positive PGC
SAMC1398429	ChIP H3K9me3 Male 23w Negative PGC rep2
SAMC1398425	ChIP H3K9me3 Male 23w Negative PGC rep1
SAMC1398420	ChIP H3K9me3 Male 23w Positive PGC rep2
SAMC1398417	ChIP H3K9me3 Male 23w Positive PGC rep1
SAMC1398412	ChIP H3K27me3 Male 23w Positive PGC rep2
SAMC1398408	ChIP H3K27me3 Male 23w Positive PGC rep1
SAMC1398404	ChIP H3K4me3 Male 23w Positive PGC rep2
SAMC1398401	ChIP H3K4me3 Male 23w Positive PGC rep1
SAMC1398396	ChIP H3K9me3 Male 21w Positive PGC rep2
SAMC1398391	ChIP H3K9me3 Male 21w Positive PGC rep1
SAMC1398384	ChIP H3K27me3 Male 21w Negative PGC rep2
SAMC1398380	ChIP H3K27me3 Male 21w Negative PGC rep1
SAMC1398376	ChIP H3K27me3 Male 21w Positive PGC rep2
SAMC1398370	ChIP H3K27me3 Male 21w Positive PGC rep1
SAMC1398368	ChIP H3K4me3 Male 21w Negative PGC rep2
SAMC1398364	ChIP H3K4me3 Male 21w Negative PGC rep1
SAMC1398360	ChIP H3K4me3 Male 21w Positive PGC rep2
SAMC1398358	ChIP H3K4me3 Male 21w Positive PGC rep1
SAMC1398354	ChIP H3K9me3 Male 15w Negative PGC rep2
SAMC1398350	ChIP H3K9me3 Male 15w Negative PGC rep1
SAMC1398346	ChIP H3K9me3 Male 15w Positive PGC rep2
SAMC1398344	ChIP H3K9me3 Male 15w Positive PGC rep1
SAMC1398340	ChIP H3K27me3 Male 15w Negative PGC rep2
SAMC1398336	ChIP H3K27me3 Male 15w Negative PGC rep1
SAMC1398333	ChIP H3K27me3 Male 15w Positive PGC rep2
SAMC1398329	ChIP H3K27me3 Male 15w Positive PGC rep1
SAMC1398326	ChIP H3K4me3 Male 15w Negative PGC rep2
SAMC1398320	ChIP H3K4me3 Male 15w Negative PGC rep1
SAMC1398318	ChIP H3K4me3 Male 15w Positive PGC rep2
SAMC1398314	ChIP H3K4me3 Male 15w Positive PGC rep1
SAMC1398310	ChIP H3K27me3 Male 12w Positive PGC rep2
SAMC1398306	ChIP H3K27me3 Male 12w Positive PGC rep1
SAMC1398302	ChIP H3K4me3 Male 12w Positive PGC rep2
SAMC1398298	ChIP H3K4me3 Male 12w Positive PGC rep1
SAMC1398294	ChIP H3K27me3 Male 10w Negative PGC
SAMC1398290	ChIP H3K27me3 Male 10w Positive PGC rep2
SAMC1398285	ChIP H3K27me3 Male 10w Positive PGC rep1
SAMC1398282	ChIP H3K4me3 Male 10w Negative PGC
SAMC1398278	ChIP H3K4me3 Male 10w Positive PGC rep2
SAMC1398274	ChIP H3K4me3 Male 10w Positive PGC rep1
SAMC1398271	ChIP H3K9me3 Male 9w Positive PGC
SAMC1398267	ChIP H3K27me3 Male 8w Positive PGC
SAMC1398264	ChIP H3K4me3 Male 8w Positive PGC