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Accession PRJCA003095
Title The non-coding and coding transcriptional landscape of the peripheral immune response in patients with COVID-19
Relevance Medical
Data types Transcriptome or Gene expression
Genome sequencing
Organisms Homo sapiens
Description We collected blood samples of 6 severe COVID-19 patients, 6 moderate COVID-19 patients and 4 healthy controls and performed multi-transcriptome sequencing of ncRNAs and mRNAs. Several miRNAs were identified to characterize possible biomarkers and therapeutic targets through co-analysis of downstream mRNAs and upstream lncRNAs. We depicted the mRNA transcriptome alteration in moderate and severe COVID-19 patients, and found evidences for heightened inflammation effect, hyperactivation of immune response and functional reduction of T cells in severe group.
Sample scope Multiisolate
Release date 2020-09-16
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 2017YFA0105800
Submitter Wenru    Su  (suwr3@mail.sysu.edu.cn)
Organization Zhongshan Ophthalmic Center,Sun Yat-sen University
Submission date 2020-07-21

Project Data

Resource name Description
BioSample (32)  show -