Accession PRJCA003155
Title Umbilical cord MSC-derived microvesicles rejuvenate aged bone marrow MSCs and slow aging-related degeneration in mice.
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description Stem cell senescence increases alongside the progressive functional declines that characterize aging. The effects of extracellular vesicles are now attracting intense interest in the context of ageing and age-related diseases. Here, we demonstrate that neonatal umbilical cord (UC) is an excellent source of microvesicles (MVs) derived from mesenchymal stem cells (MSC-MVs). These UC produced MSC-MVs (UC-MVs) contain abundant anti-aging signals and rejuvenate senescing adult bone marrow MSCs (AB-MSCs). UC-MV-rejuvenated AB-MSCs exhibited alleviated aging phenotypes and increased self-renewal capacity and telomere length. Mechanistically, UC-MVs rejuvenates AB-MSCs at least partially by transferring proliferating cell nuclear antigen (PCNA) into recipient AB-MSCs. When tested in therapeutic context, UC-MV-triggered rejuvenation enhances the capacities of AB-MSCs in bone formation, wound healing, and angiogenesis. We also directly intravenously injected UC-MVs into aged mice, which conferred anti-aging phenotypes including decreased bone and kidney degeneration. Our findings reveal that UC-MVs are of high translational value in anti-aging intervention.
Sample scope Monoisolate
Release date 2020-10-09
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 31822030
National Natural Science Foundation of China (NSFC) 31801154
National Natural Science Foundation of China (NSFC) 31771458
Ministry of Science and Technology of the People's Republic of China (MOST) 2017YFA0700403
China Postdoctoral Science Foundation funded project 2017M622455
China Postdoctoral Science Foundation funded project 2019T120664
Submitter An-Yuan    Guo  (guoay@hust.edu.cn)
Organization Huazhong University of Science and Technology
Submission date 2020-10-09

Project Data

Resource name Description