Accession |
PRJCA003155 |
Title |
Umbilical cord MSC-derived microvesicles rejuvenate aged bone marrow MSCs and slow aging-related degeneration in mice. |
Relevance |
Medical |
Data types |
Transcriptome or Gene expression
|
Organisms |
Homo sapiens
|
Description |
Stem cell senescence increases alongside the progressive functional declines that characterize aging. The effects of extracellular vesicles are now attracting intense interest in the context of ageing and age-related diseases. Here, we demonstrate that neonatal umbilical cord (UC) is an excellent source of microvesicles (MVs) derived from mesenchymal stem cells (MSC-MVs). These UC produced MSC-MVs (UC-MVs) contain abundant anti-aging signals and rejuvenate senescing adult bone marrow MSCs (AB-MSCs). UC-MV-rejuvenated AB-MSCs exhibited alleviated aging phenotypes and increased self-renewal capacity and telomere length. Mechanistically, UC-MVs rejuvenates AB-MSCs at least partially by transferring proliferating cell nuclear antigen (PCNA) into recipient AB-MSCs. When tested in therapeutic context, UC-MV-triggered rejuvenation enhances the capacities of AB-MSCs in bone formation, wound healing, and angiogenesis. We also directly intravenously injected UC-MVs into aged mice, which conferred anti-aging phenotypes including decreased bone and kidney degeneration. Our findings reveal that UC-MVs are of high translational value in anti-aging intervention. |
Sample scope |
Monoisolate |
Release date |
2020-10-09 |
Grants |
Agency |
program |
Grant ID |
Grant title |
National Natural Science Foundation of China (NSFC)
|
|
31822030
|
|
National Natural Science Foundation of China (NSFC)
|
|
31801154
|
|
National Natural Science Foundation of China (NSFC)
|
|
31771458
|
|
Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2017YFA0700403
|
|
China Postdoctoral Science Foundation funded project
|
|
2017M622455
|
|
China Postdoctoral Science Foundation funded project
|
|
2019T120664
|
|
|
Submitter |
An-Yuan
Guo (guoay@hust.edu.cn)
|
Organization |
Huazhong University of Science and Technology |
Submission date |
2020-10-09 |