项目编号 PRJCA003259
项目标题 Germline Mutation Landscape in Chinese Prostate Cancer Patients
涉及领域 Medical
数据类型 Whole genome sequencing
物种名称 Homo sapiens
描述信息 Prostate cancer (PCa) is recognized as one of the most heritable cancers. Recently, DNA repair deficiency has emerged as a potential driver of PCa. Compared with the general population, the risk of PCa is estimated to be higher for carriers with germlineBRCA1 or BRCA2 mutations, respectively. Moreover, the frequency of germline mutation (12%) of DNA repair genes (DRGs) in men with metastatic PCa is higher than that in the general population. Owing to the high proportion of germline mutation carriers, a guideline for genetic testing was established. Aiming to clarify the landscape of germline DRG mutation in Chinese patients with PCa, we sequenced patients for germline variants.
样品范围 Multiisolate
发布日期 2020-08-15
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
33006389 Prevalence of comprehensive DNA damage repair gene germline mutations in Chinese prostate cancer patients International Journal of Cancer 10.1002/ijc.33324 2021
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Fudan University Shanghai Cancer Center N/A
提交者 Yao Zhu (yaozhu09@fudan.edu.cn)
提交单位 Fudan university Shanghai Cancer Center
提交日期 2020-08-15

项目包含数据信息

资源名称 描述
BioSample (246)  show -