| Accession |
PRJCA003560 |
| Title |
Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Neurogenesis processes differ in different areas of the cortex in many species, including humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and pons during human embryonic and fetal development. We identified distinct subtypes of neural progenitor cells (NPCs) and their molecular signatures, including a group of previously unidentified transient NPCs. We specified the neurogenesis path and molecular regulations of the human deep-layer, upper-layer, and mature neurons. Additionally, we verified region-specific characteristics of neurons in the cortex, including their distinct electro- physiological features. |
| Sample scope |
Single cell |
| Release date |
2020-09-28 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
31625018
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31230047
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81521002
|
|
| National Natural Science Foundation of China (NSFC)
|
|
91732301
|
|
|
|
| Submitter |
Fuchou
Tang (tangfuchou@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2020-09-28 |
