| Accession |
PRJCA003643 |
| Title |
The HIF1A antisense long non-coding RNA drives a positive feedback loop of HIF1A mediated transactivation and glycolysis |
| Relevance |
Medical |
| Data types |
Epigenomics
|
| Organisms |
Homo sapiens
|
| Description |
We demonstrate that a HIF1A anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF1A-mediated transactivation and glycolysis. HIF1A induces HIFAL transcription, which forms a positive feed-forward loop to maintain the transactivation activity of HIF1A. |
| Sample scope |
Monoisolate |
| Release date |
2021-01-20 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33637716
|
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
|
Nature Communications
|
10.1038/s41467-021-21535-3
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2016YFC1302300
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81720108029
|
|
|
|
| Submitter |
Zifeng
Wang (wangzf@sysucc.org.cn)
|
| Organization |
Sun Yat-sen University |
| Submission date |
2020-10-12 |
