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Accession PRJCA003644
Title Reconstruction of immune microenvironment and signaling pathways in endometrioid endometrial adenocarcinoma during formation of lymphovascular space involvement and lymph node metastasis
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description The amplification or mutation of oncogenes and escape from immune surveillance systems promote tumor metastasis. However, subtle changes in the immune microenvironment and signaling pathways are poorly understood during the formation of lymphovascular space involvement (LVSI) and lymph node (LN) metastasis of endometrioid endometrial adenocarcinoma(EEA). We detected tumor immunology-related signaling pathways and immunocyte subtypes according to the mRNA levels of 750 oncogenes and genes relating to the tumor microenvironment and immune response using the Nanostring PanCancer IO 360 Panel in 24 paraffin-embedded tissues of EEAs and benign gynecological diseases. Internal reference genes were used for data normalization.
Sample scope Multiisolate
Release date 2020-10-13
Publication
PubMed ID Article title Journal name DOI Year
33363026 Reconstruction of Immune Microenvironment and Signaling Pathways in Endometrioid Endometrial Adenocarcinoma During Formation of Lymphovascular Space Involvement and Lymph Node Metastasis Frontiers in Oncology 10.3389/fonc.2020.595082 2020
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) Young Scientists Fund 81802607
Submitter Jianliu    Wang  (wangjianliu@pkuph.edu.cn)
Organization Peking University People's Hospital
Submission date 2020-10-12

Project Data

Resource name Description
BioSample (24)  show -
GSA (1) -
CRA003336 Reconstruction of immune microenvironment and signaling pathways in endometrioid endometrial adenocarcinoma during formation of lymphovascular space involvement and lymph node metastasis