| Description |
A comprehensive transcriptome survey of pig (Sus scrofa), provides information essential for a complete understanding of the mechanisms of tissue specialization that underlies economic traits in pig and accelerate the use of pig as a biomedical model. We enhanced the definition of four distinct transcripts for 31 adult tissues and two cell lines of pig, and characterize the transcriptomic features and variability with respect to the known physiology of tissues. We demonstrated the extraordinary diversity among 47 anatomically distinct skeletal muscles, as well as among six adipose depots, which link to their diverse origins, metabolic features, heterogeneous composition, physical activities and mitochondrial pathways. Comparing the transcriptomes of seven homologous tissues of pig with those of nine vertebrates provided insights into the evolutionary divergence in transcription that contributed to the lineage-specific tissue biology. We also jointly analysed the long-range regulation of promoters by their enhancers with downstream transcription in subcutaneous adiposes for six mammals, and illuminated the evolutionary stability of transcription is mainly contribute to the multiple enhancers serve to buffer transcriptional patterns for a target protein coding gene against genetic perturbations, thereby conferring robustness during speciation. |
