| Accession |
PRJCA003826 |
| Title |
Single-cell transcriptome profiling of the vitamin C-deficient kidney identified key cell types and epimutations to acute kidney injury |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Mus musculus
|
| Description |
The recently described roles of vitamin C as an epigenetic regulator playsa crucial role in normal physiological development and pathological conditions.However, the epigenetic regulatory role of vitamin C in renal homeostasis andpathogenesis remains largely unknown. We aim to reveal that vitamin C deficiency promoted acute kidney injury,and provide a potential mechanism for epigenetic therapy in preventing the progression of chronic kidney disease. |
| Sample scope |
Multiisolate |
| Release date |
2021-12-03 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34983833
|
Vitamin C Deficiency Causes Cell Type–Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model
|
Journal of the American Society of Nephrology
|
10.1681/ASN.2021070881
|
2022
|
| 36127710
|
Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways
|
Clinical Epigenetics
|
10.1186/s13148-022-01333-4
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDA16010102
|
|
| Chinese Academy of Sciences (CAS)
|
the National Key R&D Program of China
|
2018YFC2000100
|
|
| Chinese Academy of Sciences (CAS)
|
the National Key R&D Program of China
|
2019YFA0110900
|
|
|
|
| Submitter |
Weimin
ci (ciwm@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2020-11-04 |
