Accession

PRJCA003878

Title

Genomic insights into the development of human liver disease to hepatocellular carcinoma

Relevance

Medical

Data types

Whole genome sequencing

Organisms

Homo sapiens

Description

Hepatocarcinogenesis is a complex multistep process, resulting from the accumulations of multiple mutations. However, the genomic alterations associated with tumor evolution have seldom been evaluated in hepatocarcinogenesis. The present study aims to investigate the genetic and evolutionary relationships among co-existing lesions of hepatocellular carcinoma (HCC), premalignant liver cirrhosis (LC) and dysplastic nodules (DN).

Sample scope

Multiisolate

Release date

2020-11-17

Grants

Agency	program	Grant ID	Grant title
Ministry of Science and Technology of the People's Republic of China (MOST)	National Science and Technology Major Project	2018ZX10723-204-004

Submitter

Zheng Wang (wzdoc@163.com)

Organization

Zhongshan Hospital, Fudan University

Submission date

2020-11-17

Project Data

Resource name	Description
BioSample (33) show	-
SAMC1548850	Hepatocellular Carcinoma fresh tumor tissue of patient Number 8
SAMC1548847	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 8
SAMC1548842	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 8
SAMC1548836	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 8
SAMC1548834	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 8
SAMC1548830	Hepatocellular Carcinoma fresh tumor tissue of patient Number 7
SAMC1548826	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 7
SAMC1548822	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 7
SAMC1548819	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 7
SAMC1548816	Hepatocellular Carcinoma fresh tumor tissue of patient Number 6
SAMC1548813	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 6
SAMC1548808	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 6
SAMC1548804	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 6
SAMC1548800	Hepatocellular Carcinoma fresh tumor tissue of patient Number 5
SAMC1548796	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 5
SAMC1548792	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 5
SAMC1548788	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 5
SAMC1548783	Hepatocellular Carcinoma fresh tumor tissue of patient Number 4
SAMC1548779	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 4
SAMC1548776	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 4
SAMC1548772	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 4
SAMC1548769	Hepatocellular Carcinoma fresh tumor tissue of patient Number 3
SAMC1548766	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 3
SAMC1548763	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 3
SAMC1548760	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 3
SAMC1548757	Hepatocellular Carcinoma fresh tumor tissue of patient Number 2
SAMC1548752	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 2
SAMC1548748	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 2
SAMC1548744	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 2
SAMC1548739	Hepatocellular Carcinoma fresh tumor tissue of patient Number 1
SAMC1548735	Hepatocellular Carcinoma fresh dysplastic nodules tissue of patient Number 1
SAMC1548731	Hepatocellular Carcinoma fresh liver cirrhosis tissue of patient Number 1
SAMC1548727	Hepatocellular Carcinoma peripheral blood mononuclear cell of patient Number 1