| Accession |
PRJCA003893 |
| Title |
Genomic profiling and prognostic value analysis of genetic alterations in Chinese resected lung cancer with invasive mucinous adenocarcinoma |
| Relevance |
Medical |
| Data types |
Variation
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. Despite previous genomic studies on lung IMA, the genetic characteristics and the prognosis-related biomarkers in Chinese surgically resected lung IMA remain unclear. We collected 76 surgically resected primary tumors of invasive lung adenocarcinoma, including 51 IMA and 25 non-mucinous adenocarcinomas (non-IMA). Comprehensive genomic profiling based on targeted next-generation sequencing (NGS) of 425 genes was explored and genomic characteristics were evaluated for the correlation with postoperative disease-free survival (DFS). Our study provided genomic insights into Chinese surgically resected lung IMA. We also identified several genomic features that may serve as potential biomarkers on postoperative recurrence in IMA patients with stage III disease. |
| Sample scope |
Multiisolate |
| Release date |
2020-12-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33505917
|
Genomic Profiling and Prognostic Value Analysis of Genetic Alterations in Chinese Resected Lung Cancer With Invasive Mucinous Adenocarcinoma
|
Frontiers in Oncology
|
10.3389/fonc.2020.603671
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81802995
|
|
| Medical Science and Technology Project of Zhejiang Province
|
|
2018KY024
|
|
|
|
| Submitter |
Youhua
Jiang (jiangyh@zjcc.org.cn)
|
| Organization |
Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital |
| Submission date |
2020-11-19 |
